Mechanism of Interferon-gamma mediated down-regulation of Interleukin-10 gene expression
نویسندگان
چکیده
منابع مشابه
Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression.
Expression of the anti-inflammatory cytokine IL-10 is suppressed by the pro-inflammatory interferon gamma but the mechanism of this action is unknown. We analysed activity of IL-10 promoter luciferase reporter constructs in transfected RPMI 8226.1 B cells that were treated at -2 h with IFNgamma (1000 U/ml) followed by stimulation with LPS (100 ng/ml) at 0 h. IFNgamma treatment suppressed LPS-in...
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ژورنال
عنوان ژورنال: Molecular Immunology
سال: 2009
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2008.11.015